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Ive observed that there are 5 obstacles patients experience with these medications as treatments for obesity and diabetes: Cost of the meds Side effects and tolerability Fear of needles Concerns about safety The moral failing of needing a medication Oral GLP1 drugs like orforglipron (Foundayo) and Wegovy work almost as well as the injectable version of these drugs The FDA just approved oral Foundayo for the treatment of obesity based on the results of the ATTAIN-1 trial, recently published in NEJM

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Effects of GLP-1RAs on HF On the whole, meta-analyses have shown that GLP-1RAs reduced the risk of developing HF ( HR = 0.62, 95% CI 0.311.02) [89]

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