Although the mechanism of action of bupropion is not fully understood, DAT inhibition is unlikely because four positron emission tomography (PET) scan studies have reported that clinically effective doses of bupropion produce very low occupancy of dopamine reuptake sites [113, 114, 115, 116]
doi:10.1002/jor.21107 Bock-Marquette I, Saxena A, White MD, DiMaio JM, Srivastava D
However, long-term treatment still appears safe and beneficial for most people with mild to moderate kidney disease
The best chance at a successful bariatric surgery is to go into it with realistic expectations, readiness for behavior changes, knowledge about nutritional and exercise requirements to keep weight off, and to plan on utilizing a team of healthcare providers after surgery for continued support.