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During anaplerosis, mitochondrial glutamate dehydrogenase 1 (GLUD1) plays a key role by catalyzing the conversion of glutamate to alpha-ketoglutarate (-KG) and releasing ammonia, which regulates autophagy and neutralizes the intracellular pH in cancer cells 19,20
Doerr, S., Giorgino, T., Martnez-Rosell, G., Damas, J
However, these observations have not been replicated in nonhuman primates or humans and are believed to be a rodent phenomenon due to the higher density of GLP-1R on rodent C cells, so the responses obtained on rodents may not be relevant to primates (Samson and Garber, 2013
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