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These enzymes are responsible for the metabolism of B(a)P to a carcinogenic compound BPDE [benzo(a)pyrene-7,8-diol-9,10-epoxide], and CYP induction is associated with damage to the DNA of spermatozoa and ROS overexpression ( Overall, the results presented here show how the use of Modified Risk Tobacco Products can induce some of the same toxicological outcomes triggered by tobacco smoking, although less marked

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doi:10.1016/j.procbio.2006.02.011 Rollini M, Musatti A, Manzoni M (2010) Production of glutathione in extracellular form by Saccharomyces cerevisiae