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Metabolic factors, such as: A higher basal metabolic rate can drive greater calorie needs More frequent hunger signals, even when a drug dampens appetite One study estimated that genetic factors explain about 30 percent of the variability in weight loss outcomes with GLP-1 receptor agonists, which helps explain why hunger persists for some users

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Given this widespread access, fitness professionals are increasingly working with clients who are using medications like Ozempic and Mounjaro, often without medical supervision

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