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The tumor-bearing mice were intravenously administered Cy7.5-labeled NP4 at a dosage of 2 mg/kg (Ru) once the tumor volume reached approximately 200 mm

Retinoid discontinuation creates the benchmark comparison since topical vitamin A derivatives (tretinoin, adapalene, retinol) represent gold-standard anti-aging treatment with decades of research and user experience documenting post-treatment outcomes

A pharmacist assessment is required before every treatment