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There were more than 333,600 participants: all Veterans Affairs users with Type 2 diabetes using GLP-1s or sulfonylureas, followed up over a period of 3 years
What that means practically: Branded, FDA-approved sermorelin products (like the historical Geref) are no longer commercially available in the US
Weight regain after stopping GLP-1 medication is well documented
The diuretic and natriuretic effects of GLP-1 are mediated through downregulation of sodiumhydrogen exchanger 3 (NHE3) activity in the renal proximal tubule that consequently affects renal hemodynamics [112]
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