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J Orthopaedic Transl 27:3343 Yunus MHM, Nordin A, Kamal H (2020) Pathophysiological perspective of osteoarthritis
Researchers suggested that additional treatments might be helpful further evaluate the study findings
Compensatory changes in the levels of weight-regulating hormones such as leptin, ghrelin, peptide YY, and gastric inhibitory peptide can counteract diet-induced weight loss, highlighting the difficulty in maintaining weight loss through diet alone [11]
This dual mechanism is significant because, as mentioned earlier, tirzepatide maintained anti-inflammatory effects even when neuronal GLP-1 receptors were knocked out in animal models
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