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In summary, considering the broad impact of ROS homeostasis on cell fate, physiopathology and therapeutic intervention, this review systematically explores the regulatory mechanisms of ROS homeostasis and highlights the pivotal role of the ROS in cell physiology
Post-translational modifications (PTMs) of redox cysteine residues of targets proteins constitute a secondary mitochondrial retrograde regulation (MRR) and can modulate ROS and RNS signaling (Hartl and Finkemeier, 2012)
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