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Additionally, low laminar flow found in smaller vessels promotes a quiescent state in ECs, while in larger vessels, higher physiological shear stress induces ECs' elongation and alignment parallel to the flow direction [208, 209]

Pharmacological studies showed that saffron supplementation has neuroprotective effects due to its main carotenoid components, such as crocin, crocetin, picrocrocin, and safranal

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Researchers often pair the two molecules in combined regenerative protocols because they engage non-overlapping pieces of the repair cascade