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162,163 The pharmacological basis of their action is increasingly being elucidated through both in vitro and in vivo experimental models, especially in conditions like IBS, peptic ulcers, GERD, and IBD, such as Crohns disease and ulcerative colitis
Thus, arginase 1 inhibitors can exert a double-strike, promoting antitumor immunity and dysregulating important metabolic pathways for tumor and CAFs cells biology/function
We found that visceral adipose tissue is particularly sensitive to changes in CI function
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