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2019;doi:10.1056/NEJMsa1909301

That would allow us to give each one what they need, or to propose a sequential treatment, first the triple agonist, first the triple agonist, then tapering to double, and finally to a single hormone. Manuel Tena, professor of Physiology at the University of Crdoba in Spain, notes that with these drugs, too much emphasis is placed on weight loss, but the effects go far beyond that, from improving the metabolic profile to enhancing insulin resistance or even reversing type 2 diabetes. However, he cautions that there is a therapeutic consensus that the application of these drugs must be paired with lifestyle changes, and the therapeutic arsenal must be reserved for cases where obesity doesnt respond to other, more common measures, such as dietary improvements or increased physical activity

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These research areas remain under investigation and require additional controlled studies to better understand the biological mechanisms involved