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increasing hydration
Women on GLP-1 drugs had an 8% lower risk of obesity-related cancers and a 20% lower risk of death from any cause, compared to those taking #DPP4 inhibitors
Long-acting agonists include liraglutide, exenatide(Bydureon), albiglutide, dulaglutide, semaglutide, PEG-loxenatide and tirzepatide, which can maintain an appropriate agonist level in plasma throughout the 24 hours of the day
Bottom Line Yes, some patients report irritability while using GLP-1 medications No, this is not common and not clearly a direct drug effect Most cases are related to under-fueling, blood sugar changes, sleep disruption, or reward pathway shifts With proper guidance and monitoring, GLP-1 medications remain safe and effective for most people If mood changes occur, they deserve attentionnot panic, but thoughtful evaluation
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