The integration of glucagon-mediated energy expenditure with the appetite-suppressive and insulinotropic effects of GIP and GLP-1 agonism is hypothesized to explain the substantial weight loss and metabolic improvements observed in Phase 2 trials
Hernandez AF, Green JB, Janmohamed S, D'Agostino RB Sr, Granger CB, Jones NP, Leiter LA, Rosenberg AE, Sigmon KN, Somerville MC
In some cases, healthcare providers may prescribe metformin and Wegovy together
12 Knight notes that her patients often report firmer skin and better elasticity, which she says aligns with the role of growth hormone and IGF-1 in supporting collagen synthesis, protein turnover, and cellular repair. Other Possible Benefits Some studies have suggested that semorelin helps with fatty liver disease, though findings remain inconsistent and are often based on small or HIV-specific populations