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Research shows that females are potentially more susceptible to T2D with chronic refined carbohydrate intake, whereas males may be more susceptible to chronic disease when chronically consuming high-fat diets, particularly those high in animal products [121, 122]

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Given the established protective properties of both SGLT-2Is and GLP-1RAs on kidney function, this finding is unexpected if it truly represents the degree of fibrosis, suggesting that the observed changes in ADC may represent other changes in kidney microstructure

Authors apologize if some references related to the main theme of the current review could not be cited due to space constraint