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Oxaloacetate (OAA) can be transaminated to aspartate by aspartate transaminase which also provides a means for nitrogen trafficking
doi: 10.1016/j.ceb.2009.04.001 133 VasuSKumanoKDardenCMRahmanILawrenceMCNaziruddinB
Additionally, glutamine deprivation or GLS1 inhibition represses glycolysis and lactate production in several cancer cells through upregulation of thioredoxin interacting protein (TXNIP) and phosphorylation of PFKFB3, potentially reducing lactate-induced differentiation of M2 macrophages (94, 95)
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