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What the gene data does (and doesnt) say Back to that headline number
PMID: 35624890
PMID 24248213
For example, in pancreatic cancer, the inflammasome component NLRP4 mediates PARPi resistance by promoting NOXO1 expression, which inhibits nuclear translocation of SIRT7, thereby enhancing ROS-induced autophagy and reactivating DDR via reduced H2AX accumulation and impaired BRCA1RAD51 complex formation
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