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S6 show that both GLP-1RA and SGLT-2 inhibitors were associated with a lower risk (13% and 14%, respectively) as compared with placebo and DPP-4 inhibitors (11% and 12%, respectively), although the difference in risks was significant for SGLT-2 vs DPP-4 inhibitors only
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To further quantify this effect, the 43/100 kDa ratio was calculated as an index of structural stabilization
Improved tolerability could therefore become an important competitive advantage if these findings translate successfully into clinical studies
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