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Here's what to expect: Prior authorization (PA) required Most plans still require approval before coverage BMI criteria apply Typically BMI (body mass index) 30, or 27 with a comorbidity (related health condition like diabetes or high blood pressure) Tier 2 or 3 placement Copays vary by employer plan Step therapy may apply Some plans require trying other treatments first Important: CVS Caremark is a pharmacy benefit manager (PBM), not an insurance company

GLP-1R agonists increase microvascular recruitment and blood flow in skeletal and cardiac muscle, even in the presence of insulin resistance, which may improve tissue oxygenation and metabolic responses [161]

During this adjustment phase, staying patient and consistent is key

Operational Dosing and Label Literacy Does Combining Them Make Sense