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Furthermore, a metabolic profiling study of 200 ME/CFS patients identified diminished serum amino acids essential for oxidative metabolism, alongside elevated expression of pyruvate dehydrogenase kinases (PDKs) in PBMCs, which inhibited pyruvate dehydrogenase (PDH)
For example, UDCA a closely related bile acid has not improved disease histology in randomized controlled trials and is not recommended in treatment guidelines.33 While TUDCA shows promise in animal NAFLD models, human studies so far have not shown improvements in liver fat, and its role in treating NAFLD remains unproven
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