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IGF-1 is one of the primary activating signals for satellite cells, and understanding how sustained IGF1R activation affects satellite cell proliferation, differentiation, and fusion is a key question in muscle biology

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It is known that single amino acid alterations in immunogenic peptides can enhance or decrease the binding of the peptide to the MHC class II molecule, causing the differentiation of CD4 T cells into Th1 cells if the binding is strong or into Th2 cells if the binding is weak [389]