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426 In contrast to AI/ML approaches that derive statistical correlations from data, mechanistic modeling builds mathematical representations based on underlying biological processes to explain and predict drug resistance

Accessed May 6, 2025

Given the redundant nature of immunosuppressive pathways in the TME, co-targeting the TIGIT/CD155 axis alongside PD-1 blockadepotentially facilitated by multi-payload nanomedicine delivery systemsrepresents a highly promising frontier for overcoming resistance and restoring robust antitumor immunity