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20 In 2017, Paul and Brady came to similar conclusions that all four forms appear to be effective, although they point out research that shows that tissue retention of cyano-B12 is lower and urinary excretion higher than that of the other forms, although this statement is based on a review from 1965
AICAR is the other non-peptide small molecule in this batch and raises the same point from a different direction, being a nucleoside whose characterisation requirements are equally unlike a peptide's
The catch is that your body cant store these vitamins for later use, meaning you need a more frequent intake to ensure you arent deficient in water-soluble vitamins
This research has implications for understanding the regulation of NAD+-dependent processes in cells
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