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More substantial improvements, if they occur, generally become apparent between months four and six
One possibility is that diminishment of NADPH also inhibits thioredoxin reductase in the cytosol, and that cytosolic glutathione becomes more oxidized because it must compensate in the reduction of reactive oxygen species for the shortage of reduced thioredoxin
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Presented for research literature review only Gondhowiardjo TD et al
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