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Acute effects of intravenous cocaine administration on serum concentrations of ghrelin, amylin, glucagon-like peptide-1, insulin, leptin and peptide YY and relationships with cardiorespiratory and subjective responses
Indications: Huntington's Chorea (a hyperkinetic movement disorder) A drug of first choice for this condition Side Effects: Sedation Depression (suicidal tendencies) Parkinsonism symptoms Lacks the hypotensive & GI side effects of reserpine due to its selectivity for central VMAT2 Pharmacokinetics: * undergoes rapid hepatic metabolism involving carbonyl reductase and CYP2D6 to 2 active metabolites -dihydrotetrabenazine (-HTBZ) and -dihydrotetrabenazine (-HTBZ), with eventual renal elimination of metabolites the -HTBZ and -HTBZ metabolites are primarily responsible for the pharmacological & therapeutic effects produced by the parent prodrug Readily crosses the blood brain barrier & depletes cerebral monoamine stores
This process is designed to mimic the natural creation of theanine in tea leaves, starting with the same compounds converted to theanine within the plant: ethylamine and L-glutamine
found that injection of Ginkgolide B (GB) , the active ingredient of terpene lactones (Wang et al., 2020), in an animal model of AD reversed the levels of TFR1 and NOCA4 and upregulated the expression of Nrf2 and GPX4 in the brains of SAMP8 mice, which exhibited neuroprotective effects in AD mice (Hbert et al., 2022)
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