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Pregnancy and breastfeeding precautions are essential
At the systemic level, GLP-1 RAs improve insulin sensitivity in peripheral tissues (muscle, adipose), reduce circulating free fatty acid flux to the liver, suppress hypothalamic appetite circuits to promote weight loss, and lower systemic pro-inflammatory cytokines (TNF-, IL-1, IL-6), thereby reducing the hepatic inflammatory milieu indirectly [7,26,30]
These results contribute to growing evidence supporting GLP-1RAs as a potential novel treatment approach for AUD, although further large-scale studies are needed
It is an essential part of the immune system
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