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By contrast, the initial studies on GLP-1RA related peptide polyagonists in animal models of NAFLD have to date provided more encouraging results as regards their effect on hepatic fibrosis (Table 2)
Ryan said an interesting observation from the trial was the difference in adverse events between the two drugs
Its a triple-agonist peptide , meaning it activates three major systems simultaneously: GLP-1 reduces hunger and slows digestion GIP enhances metabolic efficiency Glucagon increases energy expenditure This combination leads to: Eating less without constant willpower Better blood sugar regulation Increased calorie burn at rest The clinical data is already strong Even in earlier trials, the results were hard to ignore: Up to ~24% total body weight loss in Phase 2 studies Around 17% weight loss in type 2 diabetes patients , alongside improved glucose control Up to 82% reduction in liver fat in individuals with fatty liver disease This isnt just weight lossits full metabolic change
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