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Safety and efficacy of a GLP-1 and glucagon receptor dual agonist mazdutide (IBI362) 9 mg and 10 mg in Chinese adults with overweight or obesity: a randomised, placebo-controlled, multiple-ascending-dose phase 1b trial
An increased emission ratio is indicative of specific binding
Immunohistochemical staining demonstrated partial Cyclin D1 expression, supporting functional activation of the MAPK pathway, whereas no mTOR staining was observed (Figures 2F,G), consistent with the epigenetic findings
The research provided insight into the metabolic contribution of the gut microbiota and the effect of metformin treatment, including the changes in the abundance of specific microbial species (increased Blautia wexlerae, a short chain fatty acid-producing species) and decreased Alistipes obesi (Alistipes genera), Roseburia sp
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