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In Kupffer cells (Louvet et al., 2011), Nrf2 and NF-B have opposing roles in regulating inflammation (Chen et al., 2022)
Because it plays such a central role, its no surprise that many people look for ways to keep their liver functioning at its best
Pegylation extends that window by attaching a polyethylene glycol chain to the peptide backbone, slowing renal clearance and giving researchers a longer usable window for site-specific study designs without eliminating the localized character of the response
however, because the greatest contributor to MASH is obesity, I believe this is more a function of weight loss than a direct effect of the medication
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