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PubMed, Embase, and the Cochrane Library were searched using keyword combinations related to GLP-1 receptor agonists, dual GLP-1/GIP agonists, and GI adverse events, from the inception of the database up to March 2025
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Although the time course of Nrf2 stabilization and nuclear translocation indicated a rapid increase with a peak at approximately 6 h for DEM, and a slow but gradual rise triggered by NFT, maximal accumulation of Nrf2 protein, as well as the induction of GCLC and glutathione synthesis, were almost identical for both NFT and DEM after incubation periods of and beyond 24 h (Fig
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