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Bkdal TA, Breitschaft A, Donsmark M, Maarbjerg SJ, Sndergaard FL, Borregaard J
AMSTAR 2 assessments indicate that the existing evidence is limited by methodological shortcomings, including incomplete reporting of excluded studies, suboptimal literature search strategies, and insufficient evaluation of how bias in primary studies may influence meta-analytic estimates
For MC1R specifically, melanocyte and melanoma-derived lines such as B16 are the traditional models
"In future studies we will aim to identify what healthcare providers can do to optimize GLP-1 outcomes, identify which patients are better treated with bariatric surgery versus GLP-1s, and determine the role out-of-pocket costs play in treatment success," said study senior author and bariatric surgeon Karan R
