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Under oxidative stress and induced by excessive ROS generation, Nrf2 is released from its inhibitor Keap1, allowing its translocation into the nucleus (Kasprzak et al., 2020), where it binds to the antioxidant response element (ARE) present in the DNA sequence of numerous antioxidant enzymes like glutathione-S-transferase, -glutamyl cysteine synthetase (glutamate cysteine ligase), heme oxygenase 1, and paraoxonase-1 inducing their transcription, managing the phase II response to oxidative stress (Kasprzak et al., 2020)
When paired with a GLP-1 receptor agonist like tirzepatide, which supports satiety and glucose control, the combination may create a synergistic effect for some individuals. However, she cautions that this isnt a one-size-fits-all treatment, and decisions regarding menopausal hormone therapy and GLP-1s must be personalized and considered in consultation with a licensed provider
When Gabby lost 100 pounds, she made good on a promise to herself: She started running
Reduces scar tissue formation
![Cardiovascular disease continuum-GLP-1 action. Adapted from [46]](https://www.researchgate.net/publication/357072789/figure/fig1/AS:1146405179654167@1650335702879/Cardiovascular-disease-continuum-GLP-1-action-Adapted-from-46.png)
