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However, as noted by the Alzheimers Drug Discovery Foundation (ADDF), virtually all trials involving epithalon have been conducted in Russia and have yet to be independently confirmed [5]

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The key anti-inflammatory effects included: Modulation of macrophage activation states Decreased reactive nitrogen species production Reduced efferocytotic activity in treated cells Lower expression of pro-inflammatory mediators Research on corneal injuries found TB-500 suppressed multiple inflammatory mediators while maintaining bacterial clearance when combined with antibiotics