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Semaglutides (Ozempic and Wegovy) are a class of molecules known as GLP-1 (Glucagon-like peptide 1) receptor agonists that mimic a hormone, GLP-1, in the body to increase the secretion of insulin, lower glucagon, control sugar spikes, and suppress appetite, leading to weight loss
129,130 They are believed to work in part by increasing the availability of serotonin and norepinephrine (also known as noradrenaline) in specific areas of the brain
Higher doses (up to 15 grams per serving) have been evaluated for safety and tolerability but have not been systematically assessed for their effects on incretin hormone secretion
Growth factor upregulation: The peptide stimulates vascular endothelial growth factor (VEGF) production and enhances the expression of growth hormone receptors, promoting angiogenesis and tissue repair
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