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People with lower CYP1A2 activity may generate reactive aflatoxin metabolites more slowly (could be a good thing), but they can still be vulnerable if downstream conjugation pathways (GSTs, UGTs) are also compromised.[ref] Related article: CYP1A2 Gene: Fast or Slow Caffeine Metabolizer and More CYP3A4 and aflatoxin G1 / other mycotoxins: CYP3A4 is involved in the metabolism of aflatoxin G1 and many other compounds, including medications
Apart from the local adverse effects of these agents, the important limitation is the localization of their effect to the site of application alone
Therefore, patients with covert encephalopathy are at a high risk for developing overt encephalopathy, and early diagnosis of covert encephalopathy is important for timely intervention
You cannot inject the powder directly
