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Visceral fat, in particular, is linked to hormonal disruptions and inflammation that accelerate aging
Peer review Peer review information Nature Reviews Gastroenterology & Hepatology thanks Alberto Camineo, Sunny Hei Wong and Bahtiyar Yilmaz for their contribution to the peer review of this work
These two substitutions , the Nle4 and D-Phe7 modifications and were introduced through the systematic structure-activity relationship programme in Victor Hrubys laboratory at the University of Arizona that established the pharmacophore requirements for melanocortin receptor agonism and produced MT-1 as a more potent, metabolically stable, and pharmacologically tractable research tool than native -MSH
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