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Next, to analyse the functional impact of SPHKAP downregulation on islet function, we employed a lentiviral shRNA approach to knock-down SPHKAP on intact islets, as most functional outputs from primary islets cannot be optimally recapitulated with dispersed islet cells due to the loss of important intra-islet cell-cell interactions

A lot of work is ongoing to understand this, Drucker told Salon in an email interview

For nausea, a significant main effect of time was observed ( 2 (3) = 14.79, p = 0.002, f = 0.54

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