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In a hybrid in-silico/in-vitro study, we aimed to (i) design and apply protocols mimicking glucose and amino-acid variations during meals on primary and iPSC-derived islets, (ii) measure on-line the corresponding cell electrical activity and coupling, (iii) build a mathematical model of islets based on these data, and (iv) introduce this model into an FDA-approved human multiorgan simulator of glucose homeostasis (UVA-PADOVA)
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