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Groups requiring caution or avoidance: Active severe depression or suicidal thoughts History of bipolar disorder or psychosis Current or previous eating disorders Adolescents (specialist supervision required) Patients with complex psychiatric conditions requiring coordinated care Regarding pregnancy, semaglutide should be discontinued at least 2 months before a planned pregnancy
To bridge the gap between preclinical findings and clinical application, future research on forskolin and carotenoids should prioritize human safety and tolerability to establish optimal dosing and formulation
