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USA 104 , 943948 (2007)

This cytokine imbalance is closely related to symptom severity, cognitive deficits, and treatment response

Additional studies in cynomolgus monkeys have confirmed the potent dose-dependent, weight-lowering effects of chronic GLP-1R/GcgR co-agonism [78], supporting the translational promise of this novel balanced agonism for obesity and type 2 diabetes