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Recent studies showed a strong relationship between intestinal tight junction loss and urinary claudin-3 levels in both a rat hemorrhagic shock model and in patients suffering from IBD or necrotizing enterocolitis, or undergoing major surgery, thereby suggesting that measurement of urinary claudin-3 can be used to some extent as non-invasive marker for intestinal tight junction loss [17]
Identity is confirmed by LC-MS, purity is measured by HPLC with UV detection, bacterial endotoxin is tested using a Limulus Amebocyte Lysate assay in accordance with USP , and microbial contamination is screened with a validated polymerase chain reaction assay
Wang W, Uzzau S, Goldblum SE, Fasano A
IV t herapy provides rapid rehydration and fluid balance, quickly restoring fluids lost due to illness, heat, or exertion
