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Sigma, Saint Louis, Missouri) Oxidative stress was assessed by the quantification of protein carbonyls and MDA using Protein Carbonyl Colorimetric and TBARS Assay Kits, respectively (Cayman Chemical, Ann Arbor, MI)

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Human telomeric protein TRF2 associates with genomic double-strand breaks as an early response to DNA damage

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These findings underscore URAT1s indispensable role in urate regulation and its potential as a therapeutic target for modulating serum urate levels

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