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CYP3A4 change | Unpredictable trough levels | Major | Measure drug levels q1 to 2 wk during dose escalation | | Levothyroxine | Gastric emptying delay | Reduced Cmax ~30% | Moderate | Administer 60 min before any other oral drug
High-resolution computed tomography scans showed that postmenopausal women with T2DM had larger cortical pores than women without T2DM
Given current market dynamics, a low-cost product may not be widely available in the near term
Participants were randomized to receive retatrutide at doses of 1, 4, 8, or 12 mg weekly, or placebo, for 48 weeks
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