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Typically occurring between ages 45 and 55, perimenopause transition is characterized by fluctuating estrogen levels and declining ovarian function that initiate a cascade of physiological and psychological changes that extend far beyond reproductive health
In addition, OAT induces proline dehydrogenase (PRODH), leading to mitochondrial ROS production, which further amplifies TGF-1 signaling and tissue fibrosis [71]
Alleviation effects of grape seed proanthocyanidin extract on inflammation and oxidative stress in a D -galactose-induced aging mouse model by modulating the gut microbiota
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