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According to FDA labeling, a gradual dose-escalation protocol allows patients to adjust over time, starting at 0.25 mg and increasing to a maintenance dose of 2.4 mg
It often coexists with POTS and shares mechanisms like mitochondrial dysfunction, systemic inflammation, and oxidative stress
Due to the above-mentioned effects of TZD on glycemic, hepatic metabolism, and inflammation, treatment with dual-agonism may reduce or reverse liver damage (lobular inflammation, hepatic steatosis, liver cell damage, and fibrosis) and metabolic dysfunction (35, 41)
The STEP clinical trials, particularly at 2.4 mg a week, revealed significant weight loss in both diabetic and non-diabetic populations, with body weight reductions ranging from 10% to 15% over extended periods (6)(23)(39)
