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The presence of GLP-1 in synovial fluid provides a biological basis for exploring its role in joint health
Weight comes back after stopping: in the STEP 1 extension, people regained about two-thirds of their lost weight within a year of stopping (Wilding and colleagues, Diabetes, Obesity and Metabolism , 2022)
The variable absorption rates observed with sublingual administration pose a challenge, requiring careful dose adjustments and individual patient monitoring to optimize treatment
Crossover designs require full elimination of both the compound and its biological effects before introducing the next treatment arm
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