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El estrato crneo, la capa ms externa de la piel, normalmente impide la penetracin de molculas con peso molecular superior a 500 Daltons (regla de Potts & Guy), mientras que los agonistas GLP-1 varan considerablemente en tamao molecular: desde aproximadamente 3,000-4,000 Daltons para semaglutida y liraglutida, hasta cerca de 59,000 Daltons para dulaglutida
GLP-1 medications were first created to help manage type 2 diabetes
Pickart L, Freedman JH, Loker WJ, Peisach J, Perkins CM, Stenkamp RE, Weinstein B
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