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The construct incorporates an N-terminal nona-D-arginine (D-Arg)9 cell-penetrating tag fused to a segment derived from the FOXO4-p53 interaction domain, giving the peptide a strongly cationic overall character driven by its multiple arginine and lysine residues, along with a single tryptophan that supports UV monitoring at 280 nm during analytical workflows
This is critical since most patients use one tirzepatide vial across several injection sessions rather than discarding it after a single dose
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This detoxification role is crucial for protecting the liver and other organs from the damaging effects of toxins
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