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The melanotic macule typically appears as a small, well-circumscribed, brown-to-black flat macule on the lip or mucous membranes, caused by increased melanin in the basal layer
Additionally, pharmacokinetic differences were predicted in subjects based on factors such as age, body weight, sex, race, ethnicity, and injection site, with most GLP-1 RAs and a dual GLP-1/GIP RA exhibiting only minor variations
Solo in caso di eccessivo dimagrimento con riduzione dell Indice di Massa Corporea sotto i 19 Kg/m2 potrebbe comportare un reale rischio di osteoporosi e di fratture da fragilit
doi: 10.1056/NEJMoa1607141 14 HernandezAFGreenJBJanmohamedSD'AgostinoRBSr.GrangerCBJonesNPet al
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