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Extended dose titration The single most effective strategy for reducing GI side effects is simply going slower with dose increases
start low and titrate up under medical advice
Unlike traditional therapies that target a single pathway, GLP-2 leverages the complementary actions of GIP and GLP-1 to deliver synergistic benefits
Initial high-throughput compound screening and further medicinal chemistry-based optimization developed two novel series of phenylurea-based compounds inhibiting GOT1 enzymatic activity with potencies in the low micromolar IC 50 range 155
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